PLoS Biology (Jul 2024)

When size matters: A novel compact Cas12a variant for in vivo genome editing.

  • Felix Bubeck,
  • Dirk Grimm

DOI
https://doi.org/10.1371/journal.pbio.3002637
Journal volume & issue
Vol. 22, no. 7
p. e3002637

Abstract

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A new study characterizes and improves a novel small Cas12a variant before adapting it for in vivo genome editing by delivery via adeno-associated virus (AAV) vectors, showcasing the potential of small CRISPR systems and their compatibility with viral vectors.