Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

Hai Wang; Lin Tian; Amit Goldstein; Jun Liu; Hin-Ching Lo; Kuanwei Sheng; Thomas Welte; Stephen T.C. Wong; Zbigniew Gugala; Fabio Stossi; Chenghang Zong; Zonghai Li; Michael A. Mancini; Xiang H.-F. Zhang

doi:10.1038/ncomms15045

Nature Communications (Apr 2017)

Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

Hai Wang,
Lin Tian,
Amit Goldstein,
Jun Liu,
Hin-Ching Lo,
Kuanwei Sheng,
Thomas Welte,
Stephen T.C. Wong,
Zbigniew Gugala,
Fabio Stossi,
Chenghang Zong,
Zonghai Li,
Michael A. Mancini,
Xiang H.-F. Zhang

Affiliations

Hai Wang: Lester and Sue Smith Breast Center, Baylor College of Medicine
Lin Tian: Lester and Sue Smith Breast Center, Baylor College of Medicine
Amit Goldstein: Lester and Sue Smith Breast Center, Baylor College of Medicine
Jun Liu: Lester and Sue Smith Breast Center, Baylor College of Medicine
Hin-Ching Lo: Lester and Sue Smith Breast Center, Baylor College of Medicine
Kuanwei Sheng: Department of Molecular and Human Genetics
Thomas Welte: Lester and Sue Smith Breast Center, Baylor College of Medicine
Stephen T.C. Wong: Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute, Weill Cornell Medical College
Zbigniew Gugala: Department of Orthopaedic Surgery and Rehabilitation, University of Texas Medical Branch
Fabio Stossi: Dan L. Duncan Cancer Center, Baylor College of Medicine
Chenghang Zong: Dan L. Duncan Cancer Center, Baylor College of Medicine
Zonghai Li: State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine
Michael A. Mancini: Dan L. Duncan Cancer Center, Baylor College of Medicine
Xiang H.-F. Zhang: Lester and Sue Smith Breast Center, Baylor College of Medicine

DOI: https://doi.org/10.1038/ncomms15045
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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The bone microenvironment may alter therapeutic responses of disseminated breast cancer cells. Here the authors establish anex vivobone metastasis model, termed BICA, to delineate the effects of bone microenvironment and to rapidly discover anti-metastasis drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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