The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review

Ariadni Androvitsanea; Kostas Stylianou; Eleni Drosataki; Ioannis Petrakis

doi:10.3390/cells10102626

Cells (Oct 2021)

The Pathophysiological Role of Heat Shock Response in Autoimmunity: A Literature Review

Ariadni Androvitsanea,
Kostas Stylianou,
Eleni Drosataki,
Ioannis Petrakis

Affiliations

Ariadni Androvitsanea: Department of Nephrology, Friedrich Alexander University, 91054 Erlangen, Germany
Kostas Stylianou: Department of Nephrology, University of Crete, 71500 Heraklion, Greece
Eleni Drosataki: Department of Nephrology, University of Crete, 71500 Heraklion, Greece
Ioannis Petrakis: Department of Nephrology, University of Crete, 71500 Heraklion, Greece

DOI: https://doi.org/10.3390/cells10102626
Journal volume & issue: Vol. 10, no. 10
p. 2626

Abstract

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Within the last two decades, there has been increasing evidence that heat-shock proteins can have a differential influence on the immune system. They can either provoke or ameliorate immune responses. This review focuses on outlining the stimulatory as well as the inhibitory effects of heat-shock proteins 27, 40, 70, 65, 60, and 90 in experimental and clinical autoimmune settings.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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