Plastic processes at ischemic injury of myocardium and role of local mitogens in its regeneration (according to the results of researches made in Scientific Center of Reconstructive and Restorative Surgery SB RAMS)

Abstract

The work presents the basic results of researches of Scientific Center of Reconstructive and Restorative Surgery SB RAMS on the issue of influence of growth factors on postinfarction remodeling of myocardium. It has been shown, that the researches defined the significance of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) for myocardium reparation after its ischemic damage. There is a description of mechanisms of regulation of bloodflow in distal parts of coronary vasculature by endothelin on different stages of formation of postinfarction cardiosclerosis. Quantitative characteristics is given of mitogens level dynamics, cell composition and activity of developing connective-tissue component in various parts of myocardium on stages of reparation after ischemic damage. The article also contains substantiation of perspective of management of growth factors dynamic for providing optimal parameters of regeneration area and improvement of pathological process outcomes.

Keywords

• vegf
• fgf
• myocardial infarction
• postinfarction cardiosclerosis
• growth factors
• vegf
• fgf
• regeneration