Effects on blood glucose, glutathione and lipid profile by Murraya in experimental animals (Rabbits)

Abstract

Background: Obesity is responsible for beta dysfunction and insulin resistance. This is main cause of type 2 diabetes and excess in glycosylated hemoglobin. The concentration of glycosylation is directly proportional to the amount of blood glucose. It is investigated that oxidative stress can play a major role in the destruction of tissue that directly link with diabetic complication. This condition also associated with elevated level of lipid peroxidation. Murraya leaves may cause hypoglycemic and hypolipidemic effects and thus reduce lipid peroxidation in experimental animals. Methodology: The animals (rabbits) were randomly divided into three groups of equal size; a control group that did not receive any sort of modification in diet throughout the study while the group 2 and 3 were orally administered 10gm of fructose and 6gm of butter in addition to normal animal chow. While a dietary modification by addition curry leaves , was made in group 3 and it received 10g curry leaves per day for the next 45 days. The blood levels of glucose, glutathione and lipid profile were measured. Results: After consumption of Murraya leaves concentration of blood glucose and LDL-C, TC, TG was significantly decreased and increased HDL-C. Glutathione evaluation was used as a parameter for the oxidative stress showed a mark decline. Conclusion: Murraya leaves acted as anti-diabetic because it is also responsible to decrease the absorption of the glucose from gastrointestinal tract and anti-hyperlipidemic effects. KEY WORDS: Murraya Koeniigi, diabetes mellitus, hypoglycemic, anti-hyperlipidemic