The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw

Deok-Won Lee; Hoon Hyun; Sungsu Lee; So  Yeon Kim; Gyu-Tae Kim; Sewook Um; Sung  Ok Hong; Heung  Jae Chun; Dae  Hyeok Yang

doi:10.3390/md17010051

Marine Drugs (Jan 2019)

The Effect of Polydeoxyribonucleotide Extracted from Salmon Sperm on the Restoration of Bisphosphonate-Related Osteonecrosis of the Jaw

Deok-Won Lee,
Hoon Hyun,
Sungsu Lee,
So Yeon Kim,
Gyu-Tae Kim,
Sewook Um,
Sung Ok Hong,
Heung Jae Chun,
Dae Hyeok Yang

Affiliations

Deok-Won Lee: Department of Oral & Maxillofacial Surgery, Kyung Hee University Dental Hospital at Gangdong, Kyung Hee University, Seoul 153-782, Korea
Hoon Hyun: Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Korea
Sungsu Lee: Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School, Gwangju 61469, Korea
So Yeon Kim: Department of Dental Hygiene, College of Health Sciences, Cheongju University, Cheongju 28503, Korea
Gyu-Tae Kim: Department of Oral and Maxillofacial Radiology, Kyung Hee University, Seoul 02447, Korea
Sewook Um: Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
Sung Ok Hong: Department of Dentistry, Catholic Kwandong University, School of Medicine, International St. Mary’s Hospital, Incheon 22711, Korea
Heung Jae Chun: Department of Biomedical Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
Dae Hyeok Yang: Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea

DOI: https://doi.org/10.3390/md17010051
Journal volume & issue: Vol. 17, no. 1
p. 51

Abstract

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Bisphosphonates (BPs) used for treating skeletal diseases can induce bisphosphonate-related osteonecrosis of the jaw (BRONJ). Despite much effort, effective remedies are yet to be established. In the present study, we investigated the feasibility of polydeoxyribonucleotide (PDRN) extracted from salmon sperm for the treatment of BRONJ, in a BRONJ-induced rat model. Compared with BRONJ-induced samples, PDRN-treated samples exhibited lower necrotic bone percentages and increased numbers of blood vessels and attached osteoclast production. Moreover, local administration of PDRN at a high concentration (8 mg/kg) remarkably resolved the osteonecrosis. Findings from this study suggest that local administration of PDRN at a specific concentration may be considered clinically for the management of BRONJ.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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