Journal of Rawalpindi Medical College (Mar 2015)
Psychiatric Disorders in First Degree Relatives of Probands with Bipolar Mood Disorder
Abstract
Background: To determine the frequency of psychiatric disorders in the first degree relatives (FDRs) of probands with bipolar mood disorder. Methods: One hundred bipolar probands were consecutively recruited from outpatient and inpatient departments of Psychiatry, Jinnah Postgraduate Medical Centre (JPMC) using ICD-10 diagnostic criteria for Bipolar mood disorder, and Urdu version of Present State Examination.(PSE). Having recorded basic socio demographic details, psychiatric morbidity in total of 300 first degree relatives were collected by using Family History-Research Diagnostic Criteria(FH-RDC) and transferred on Performa for statistical analysis. Results: Out of the 300 first degree relatives of bipolar probands, 34% had psychiatric disorders, Depressive disorder being the commonest found in 9% first degree relatives, followed by bipolar mood disorder in 7% first degree relatives , drug use disorder in 6% first degree relatives, antisocial personality in 5% first degree relatives, alcoholism in 2% first degree relatives, chronic schizophrenia in 2% first degree relatives , schizoaffective disorder in 1.67%, unspecified psychosis in 0.67% and other psychiatric disorders in 1% first degree relatives. These were common in the age group of 15-24 years Conclusion: The psychiatric disorders aggregated amongst the first degree relatives of bipolar probands were depressive disorder( with the highest frequency) followed by bipolar mood disorder, schizophrenia, schizoaffective disorder, drug use disorder, alcoholism and antisocial personality disorder.
