A Randomized, Open Label, Exploratory Trial Comparing Efficacy of Amantadine and Ropinirole in Restless Legs Syndrome

Govind Madhaw; Ravi Gupta; Puneet Dhamija; Niraj Kumar

doi:10.1055/s-0043-1770810

Sleep Science (Jun 2023)

A Randomized, Open Label, Exploratory Trial Comparing Efficacy of Amantadine and Ropinirole in Restless Legs Syndrome

Govind Madhaw,
Ravi Gupta,
Puneet Dhamija,
Niraj Kumar

Affiliations

Govind Madhaw: Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Ravi Gupta: Division of Sleep Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Puneet Dhamija: Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Niraj Kumar: ORCiD; Department of Neurology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

DOI: https://doi.org/10.1055/s-0043-1770810
Journal volume & issue: Vol. 16, no. 02
pp. 174 – 182

Abstract

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Objective Amantadine has both anti-glutamatergic and dopaminergic action and may improve restless legs syndrome (RLS). We compared the efficacy and adverse-effect profile of amantadine and ropinirole in RLS.

Published in Sleep Science

ISSN: 1984-0659 (Print); 1984-0063 (Online)
Publisher: Thieme Revinter Publicações Ltda.
Country of publisher: Brazil
LCC subjects: Philosophy. Psychology. Religion: Psychology: Consciousness. Cognition
Website: https://lp.thieme.de/journals/sleep-science/1984-0063

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