Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2

Molly Brady; Conor McQuaid; Alexander Solorzano; Angelique Johnson; Abigail Combs; Chethana Venkatraman; Akib Rahman; Hannah Leyva; Wing-Chi Edmund Kwok; Ronald W. Wood; Rashid Deane

doi:10.1038/s42003-021-02856-x

Communications Biology (Nov 2021)

Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2

Molly Brady,
Conor McQuaid,
Alexander Solorzano,
Angelique Johnson,
Abigail Combs,
Chethana Venkatraman,
Akib Rahman,
Hannah Leyva,
Wing-Chi Edmund Kwok,
Ronald W. Wood,
Rashid Deane

Affiliations

Molly Brady: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Conor McQuaid: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Alexander Solorzano: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Angelique Johnson: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Abigail Combs: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Chethana Venkatraman: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Akib Rahman: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Hannah Leyva: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Wing-Chi Edmund Kwok: Department of Imaging Sciences, University of Rochester
Ronald W. Wood: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester
Rashid Deane: Department of Neuroscience, Del Monte Institute of Neuroscience, University of Rochester

DOI: https://doi.org/10.1038/s42003-021-02856-x
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Brady et al. demonstrate that spike protein-targeting antibodies reduce SARS-CoV-2 biodistribution. This highlights potential avenues for vaccine development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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