Frontiers in Medicine (May 2018)

The Stromal Vascular Fraction From Fat Tissue in the Treatment of Osteochondral Knee Defect: Case Report

  • Ramil Z. Salikhov,
  • Ramil Z. Salikhov,
  • Ruslan F. Masgutov,
  • Ruslan F. Masgutov,
  • Mikhail A. Chekunov,
  • Leysan G. Tazetdinova,
  • Galina Masgutova,
  • Oleg V. Teplov,
  • Damir Galimov,
  • Damir Galimov,
  • Yuri Plakseichuk,
  • Ramil Yagudin,
  • Igor O. Pankov,
  • Albert Rizvanov,
  • Albert Rizvanov

DOI
https://doi.org/10.3389/fmed.2018.00154
Journal volume & issue
Vol. 5

Abstract

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In this study we applied autologous fat tissue stromal vascular fraction (SVF) cells in combination with microfracturing technique in a 36-year-old man with an osteochondral lesion of the medial femoral condyle 8 months after the injury. Cell material was generated by fat tissue liposuction from the anterior abdominal wall with subsequent extraction of the SVF and injected through a mini-arthrotomy portal with subsequent fibrin sealant fixation. The follow-up period was 2 years. Clinical score improved from 23 to 96 according to IKDC and from 10 to 90 according to EQ-VAS at 24 months follow-up. Magnetic resonance imaging (MRI) before the surgery revealed an osteochondral lesion with development of significant trabecular edema that remained unchanged for 6 months despite conservative treatment. MRI 1 and 2 years after the surgery showed the recovery of the damaged cartilage thickness with somewhat uneven structure and a decrease in the trabecular edema of the femoral condyle. The use of SVF cells with fibrin sealant fixation might be a promising approach in the treatment of osteochondral joint lesions. Further studies are required.

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