CAD, myocardial infarction and stroke. Prevalence, associations, impact on outcomes (according to the MERIDIAN-RO study)

Abstract

The article presents the results of MERIDIAN-RO, a prospective cohort cross-sectional study with retrospective component. The study aimed to evaluate the incidence of ischemic heart disease, myocardial infarction and stroke in the working population of the Ryazan region, their association with risk factors, treatments and impact on mortality. In 2011, 1622 people (1220 urban and 402 rural) aged 25--64 years (mean age - 43,4 ± 11,4 years) 42.6% of which were males and 53.8% females, were included in the study. The cohort was observed for 36 months, the end points were evaluated annually. Considering the low incidence of CAD, myocardial infarction and stroke, the data were combined into one end point CAD/myocardial infarction/stroke. According to the study, the incidence of CAD/myocardial infarction/stroke was lower than on average in the Russian Federation. The main factors contributing to reaching the point of CAD/stroke/myocardial infarction were hypertension, CRP above 5 mg/l, fibrinogen above 4 g/l, apolipoprotein B above 180 mg/dl, anxiety/depression, family history of stroke and myocardial infarction, and obesity. CAD/myocardial infarction/stroke increased the burden on the healthcare system and the burden of CVD. This calls for the need to enhance treatment of these patients.

Keywords

• факторы риска
• инфаркт миокарда
• инсульт
• ишемическая болезнь сердца
• risk factors
• myocardial infarction
• stroke
• coronary artery disease