Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy

Ribnikar Domen; Horvat Valentina Jeric; Ratosa Ivica; Veitch Zachary W; Grcar Kuzmanov Biljana; Novakovic Srdjan; Langerholc Erik; Amir Eitan; Seruga Bostjan

doi:10.2478/raon-2023-0027

Radiology and Oncology (Jun 2023)

Association between PIK3CA activating mutations and outcomes in early-stage invasive lobular breast carcinoma treated with adjuvant systemic therapy

Ribnikar Domen,
Horvat Valentina Jeric,
Ratosa Ivica,
Veitch Zachary W,
Grcar Kuzmanov Biljana,
Novakovic Srdjan,
Langerholc Erik,
Amir Eitan,
Seruga Bostjan

Affiliations

Ribnikar Domen: Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Horvat Valentina Jeric: Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Ratosa Ivica: Faculty of Medicine Ljubljana, University of Ljubljana, Ljubljana, Slovenia
Veitch Zachary W: Division of Medical Oncology and Hematology, Royal Victoria Hospital, Bariie, Ontario, USA
Grcar Kuzmanov Biljana: Department of Pathology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Novakovic Srdjan: Department of Molecular Diagnostics, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Langerholc Erik: Institute of Biostatistics and informatics, Faculty of Medicine Ljubljana, University of Ljubljana, Ljubljana, Slovenia
Amir Eitan: Division of Medical Oncology and Hematology, University of Toronto and Princess Margaret Cancer Centre, Toronto, Canada
Seruga Bostjan: Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia

DOI: https://doi.org/10.2478/raon-2023-0027
Journal volume & issue: Vol. 57, no. 2
pp. 220 – 228

Abstract

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The aim of the study was to evaluate the independent prognostic role of PIK3CA activating mutations and an association between PIK3CA activating mutations and efficacy of adjuvant endocrine therapy (ET) in patients with operable invasive lobular carcinoma (ILC).

Published in Radiology and Oncology

ISSN: 1581-3207 (Online)
Publisher: Sciendo
Country of publisher: Slovenia
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://sciendo.com/journal/RAON

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Abstract

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