Nature Communications (Feb 2018)
A microengineered vascularized bleeding model that integrates the principal components of hemostasis
- Yumiko Sakurai,
- Elaissa T. Hardy,
- Byungwook Ahn,
- Reginald Tran,
- Meredith E. Fay,
- Jordan C. Ciciliano,
- Robert G. Mannino,
- David R. Myers,
- Yongzhi Qiu,
- Marcus A. Carden,
- W. Hunter Baldwin,
- Shannon L. Meeks,
- Gary E. Gilbert,
- Shawn M. Jobe,
- Wilbur A. Lam
Affiliations
- Yumiko Sakurai
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Elaissa T. Hardy
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Byungwook Ahn
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Reginald Tran
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Meredith E. Fay
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Jordan C. Ciciliano
- George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology
- Robert G. Mannino
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- David R. Myers
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Yongzhi Qiu
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- Marcus A. Carden
- Department of Pediatrics, Divisoin of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
- W. Hunter Baldwin
- Department of Pediatrics, Divisoin of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
- Shannon L. Meeks
- Department of Pediatrics, Divisoin of Pediatric Hematology/Oncology, Aflac Cancer Center and Blood Disorders Center of Children’s Healthcare of Atlanta, Emory University School of Medicine
- Gary E. Gilbert
- Medicine Depts of VA Boston Healthcare System and Harvard Medical School
- Shawn M. Jobe
- Blood Center of Wisconsin
- Wilbur A. Lam
- Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University
- DOI
- https://doi.org/10.1038/s41467-018-02990-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Hemostasis is a complex ensemble of events, but current bleeding assays only analyze single components like coagulation or platelet function. Here the authors present a comprehensive vascularized microfluidic mechanical injury bleeding model that addresses different aspects of the hemostatic process.
