Frontiers in Cardiovascular Medicine (Sep 2022)
Superior prognostic value of right ventricular free wall compared to global longitudinal strain in patients with repaired tetralogy of Fallot
- Ying Gao,
- Ying Gao,
- Ying Gao,
- Ying Gao,
- He Li,
- He Li,
- He Li,
- Lin He,
- Lin He,
- Lin He,
- Yanting Zhang,
- Yanting Zhang,
- Yanting Zhang,
- Wei Sun,
- Wei Sun,
- Wei Sun,
- Meng Li,
- Lang Gao,
- Lang Gao,
- Lang Gao,
- Yixia Lin,
- Yixia Lin,
- Yixia Lin,
- Mengmeng Ji,
- Mengmeng Ji,
- Mengmeng Ji,
- Qing Lv,
- Qing Lv,
- Qing Lv,
- Jing Wang,
- Jing Wang,
- Jing Wang,
- Li Zhang,
- Li Zhang,
- Li Zhang,
- Mingxing Xie,
- Mingxing Xie,
- Mingxing Xie,
- Yuman Li,
- Yuman Li,
- Yuman Li
Affiliations
- Ying Gao
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Ying Gao
- Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
- Ying Gao
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Ying Gao
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- He Li
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- He Li
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- He Li
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Lin He
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Lin He
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Lin He
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yanting Zhang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yanting Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yanting Zhang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Wei Sun
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Wei Sun
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Wei Sun
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Meng Li
- Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China
- Lang Gao
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Lang Gao
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Lang Gao
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yixia Lin
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yixia Lin
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yixia Lin
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Mengmeng Ji
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Mengmeng Ji
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Mengmeng Ji
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Qing Lv
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Qing Lv
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Qing Lv
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Jing Wang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Jing Wang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Jing Wang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Li Zhang
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Li Zhang
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Li Zhang
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Mingxing Xie
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Mingxing Xie
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Mingxing Xie
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- Yuman Li
- Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Yuman Li
- Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China
- Yuman Li
- Clinical Research Center for Medical Imaging in Hubei Province, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2022.996398
- Journal volume & issue
-
Vol. 9
Abstract
ObjectivesBoth right ventricular free wall longitudinal strain (RVFWLS) and right ventricular global longitudinal strain (RVGLS) using two-dimensional speckle tracking echocardiography (2D-STE) has been demonstrated to predict adverse outcomes in patients with repaired tetralogy of Fallot (r-TOF). However, RVGLS may be affected by left ventricular (LV) function owing to the fact that the interventricular septum is also a part of the left ventricle. Therefore, the aim of our study was to compare the predictive value of RVFWLS with that of RVGLS in patients with r-TOF.Materials and methodsA total of 179 patients with r-TOF were included in this study. RVFWLS, RVGLS, and left ventricle global longitudinal strain (LVGLS) were evaluated by 2D-STE. The adverse clinical events were death or r-TOF-related rehospitalization. Prognostic performance was evaluated by C-statistic and Akaike information criterion (AIC).ResultsThirty-one patients developed poor outcomes during a median follow-up period of 2.8 years. Compared with patients without end-point events, those with end-point events had higher incidence of moderate/severe pulmonary regurgitation, larger right heart sizes, and lower RV fractional area change (RVFAC), RVFWLS, RVGLS, and LVGLS than those without. Multivariate Cox regression analysis revealed that RVFAC, RVFWLS, RVGLS, and LVGLS were predictive of poor outcomes in patients with r-TOF after adjustment for transannular patch and QRS duration. A Cox model using RVFWLS (C index = 0.876, AIC = 228) was found to predict unfavorable outcomes more accurately than a model with RVGLS (C index = 0.856, AIC = 243), RVFAC (C index = 0.811, AIC = 248), and LVGLS (C index = 0.830, AIC = 248).ConclusionAlthough both RVGLS and RVFWLS are associated with adverse events, RVFWLS provides superior prognostic value than that of RVGLS in patients with r-TOF.
Keywords
