Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells

Renan B. Ferreira; Ling Fu; Youngeun Jung; Jing Yang; Kate S. Carroll

doi:10.1038/s41467-022-33124-z

Nature Communications (Sep 2022)

Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells

Renan B. Ferreira,
Ling Fu,
Youngeun Jung,
Jing Yang,
Kate S. Carroll

Affiliations

Renan B. Ferreira: Department of Chemistry, UF Scripps Biomedical Research
Ling Fu: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics
Youngeun Jung: Department of Chemistry, UF Scripps Biomedical Research
Jing Yang: State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics
Kate S. Carroll: Department of Chemistry, UF Scripps Biomedical Research

DOI: https://doi.org/10.1038/s41467-022-33124-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Fluorogenic detection of H2O2 in cells is established, but equivalent tools to monitor its cellular targets remain in their infancy. Here authors develop fluorogenic probes for detecting cysteine sulfenic acid, a redox modification inextricably linked to H2O2 signalling and oxidative stress.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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