mTORC2 confers neuroprotection and potentiates immunity during virus infection

Rahul K. Suryawanshi; Chandrashekhar D. Patil; Alex Agelidis; Raghuram Koganti; Joshua M. Ames; Lulia Koujah; Tejabhiram Yadavalli; Krishnaraju Madavaraju; Lisa M. Shantz; Deepak Shukla

doi:10.1038/s41467-021-26260-5

Nature Communications (Oct 2021)

mTORC2 confers neuroprotection and potentiates immunity during virus infection

Rahul K. Suryawanshi,
Chandrashekhar D. Patil,
Alex Agelidis,
Raghuram Koganti,
Joshua M. Ames,
Lulia Koujah,
Tejabhiram Yadavalli,
Krishnaraju Madavaraju,
Lisa M. Shantz,
Deepak Shukla

Affiliations

Rahul K. Suryawanshi: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Chandrashekhar D. Patil: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Alex Agelidis: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Raghuram Koganti: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Joshua M. Ames: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Lulia Koujah: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Tejabhiram Yadavalli: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Krishnaraju Madavaraju: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago
Lisa M. Shantz: Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine
Deepak Shukla: Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago

DOI: https://doi.org/10.1038/s41467-021-26260-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

The immune response to herpes simplex virus is essential in limiting immunopathology during infection, however factors linked to neuroprotection are currently unclear. Here the authors implicate mTORC2 in the host response to viral infection and link to neuroprotection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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