Outcomes of Hospitalized Patients with Infective Endocarditis: A Tertiary Center Experience

Abstract

Objective:The purpose of this study is to report our experience with a comprehensive view of patients hospitalized in tertiary level center with a diagnosis of infective endocarditis (IE).Method:Medical records of patients who were hospitalized with a diagnosis of IE between January 2017 and December 2019 were retrospectively reviewed by using hospital database. Two groups were generated as survivors and non-survivors. Surgical intervention, occurrence of complications, and in-hospital and 30-day mortality data were noted.Results:A total of 53 patients (58.5% male) were included in this singlecenter retrospective study. Native valve endocarditis was more common (86.8%) and located in mitral position. Seven patients had mechanical prosthetic valve infection, those were also in mitral position. Most of the patients (92.4%) had vegetation size greater than 10 mm. Thirty-one patients (58.5%) had culture negative endocarditis while Staphylococcus aureus was the most common (9.4%) cultured organism. In-hospital or 30-day mortality was found 35.8%. The rate of embolism was 45.3%. Risk factors associated with mortality included advanced age, lower body mass index, being in NYHA III/IV status, development of acute renal failure and embolic phenomenon, septic shock, congestive heart failure, and presence of tricuspid regurgitation higher than moderate degree. Early valve surgery seems to improve the prognosis of IE according to our findings.Conclusion:Advanced age, lower BMI, being in NYHA III/IV status, previous history of hypertension, presence of tricuspid valve regurgitation higher than moderate degree, occurrence of acute renal failure, embolic phenomenon, septic shock, and congestive heart failure was found as risk factors for mortality. Early valve surgery may improve prognosis of IE according to our study.

Keywords

• heart valve disease
• infective endocarditis
• prognosis