Abnormally primed CD8 T cells: The Achilles’ heel of CHB

Xiaoqing Chen; Xue Liu; Yichao Jiang; Ningshao Xia; Ningshao Xia; Ningshao Xia; Chao Liu; Chao Liu; Wenxin Luo; Wenxin Luo

doi:10.3389/fimmu.2023.1106700

Frontiers in Immunology (Mar 2023)

Abnormally primed CD8 T cells: The Achilles’ heel of CHB

Xiaoqing Chen,
Xue Liu,
Yichao Jiang,
Ningshao Xia,
Ningshao Xia,
Ningshao Xia,
Chao Liu,
Chao Liu,
Wenxin Luo,
Wenxin Luo

Affiliations

Xiaoqing Chen: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Xue Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Yichao Jiang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Ningshao Xia: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Ningshao Xia: Xiang An Biomedicine Laboratory, Xiamen, Fujian, China
Ningshao Xia: The Research Unit of Frontier Technology of Structural Vaccinology, Chinese Academy of Medical Sciences, Xiamen, Fujian, China
Chao Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Chao Liu: State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China
Wenxin Luo: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China
Wenxin Luo: Xiang An Biomedicine Laboratory, Xiamen, Fujian, China

DOI: https://doi.org/10.3389/fimmu.2023.1106700
Journal volume & issue: Vol. 14

Abstract

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Chronic hepatitis B virus (HBV) infection continues to be a significant public health challenge, and more than 250 million people around world are infected with HBV. The clearance of HBV with virus-specific CD8 T cells is critical for a functional cure. However, naïve HBV-specific CD8 T cells are heavily hindered during the priming process, and this phenomenon is closely related to abnormal cell and signal interactions in the complex immune microenvironment. Here, we briefly summarize the recent progress in understanding the abnormal priming of HBV-specific CD8 T cells and some corresponding immunotherapies to facilitate their functional recovery, which provides a novel perspective for the design and development of immunotherapy for chronic HBV infection (CHB). Finally, we also highlight the balance between viral clearance and pathological liver injury induced by CD8 T-cell activation that should be carefully considered during drug development.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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