Nature Communications (Nov 2022)
Gut to lung translocation and antibiotic mediated selection shape the dynamics of Pseudomonas aeruginosa in an ICU patient
- Rachel M. Wheatley,
- Julio Diaz Caballero,
- Thomas E. van der Schalk,
- Fien H. R. De Winter,
- Liam P. Shaw,
- Natalia Kapel,
- Claudia Recanatini,
- Leen Timbermont,
- Jan Kluytmans,
- Mark Esser,
- Alicia Lacoma,
- Cristina Prat-Aymerich,
- Antonio Oliver,
- Samir Kumar-Singh,
- Surbhi Malhotra-Kumar,
- R. Craig MacLean
Affiliations
- Rachel M. Wheatley
- University of Oxford, Department of Biology
- Julio Diaz Caballero
- University of Oxford, Department of Biology
- Thomas E. van der Schalk
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp
- Fien H. R. De Winter
- Molecular Pathology Group, Laboratory of Cell Biology and Histology, Faculty of Medicine, University of Antwerp
- Liam P. Shaw
- University of Oxford, Department of Biology
- Natalia Kapel
- University of Oxford, Department of Biology
- Claudia Recanatini
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Leen Timbermont
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp
- Jan Kluytmans
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Mark Esser
- Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca
- Alicia Lacoma
- Microbiology Department, Hospital Universitari Germans Trias i Pujol, Institut d’Investigació Germans Trias i Pujol, CIBER Enfermedades Respiratorias, Universitat Autònoma de Barcelona
- Cristina Prat-Aymerich
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
- Antonio Oliver
- Servicio de Microbiología, Hospital Universitari Son Espases, Instituto de Investigación Sanitaria Illes Balears (IdISBa)
- Samir Kumar-Singh
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp
- Surbhi Malhotra-Kumar
- Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp
- R. Craig MacLean
- University of Oxford, Department of Biology
- DOI
- https://doi.org/10.1038/s41467-022-34101-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
In this paper the authors show that the pathogenic bacterium Pseudomonas aeruginosa migrates between the gut and lungs of an ICU patient, and that differential evolutionary responses to antibiotic treatment occur in these organs.
