Nature Communications (Nov 2017)

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

  • Lorena Zuliani-Alvarez,
  • Anna M. Marzeda,
  • Claire Deligne,
  • Anja Schwenzer,
  • Fiona E. McCann,
  • Brian D. Marsden,
  • Anna M. Piccinini,
  • Kim S. Midwood

DOI
https://doi.org/10.1038/s41467-017-01718-7
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli.