Features of the microbiota for various malignant neoplasms

Abstract

The development of omics technologies and sequencing has significantly expanded the understanding of the role of microorganisms that inhabit various human organs and collectively make up its microbiota in the development of cancer. The extensive literature of recent years devoted to various aspects of the participation of the microbiota in carcinogenesis substantiates the relevance of analyzing the impact of its features on the processes of carcinogenesis in various human organs.Purpose of the study. Analysis of literature data on the key issues of the relationship between the human microbiome and the risk of cancer and explore possible prospects for its use in the diagnosis, therapy and prevention of cancer.Materials and methods. A literature search was carried out in the databases NCBI MedLine (PubMed), Scopus, Web of Science, based on an extended list of keywords that included all the localizations of malignant neoplasms (MNs) considered in the review. Original studies, meta-analyses, randomized controlled trials, and reviews published in recent years were used.Results. Recent studies using omics technologies have shown significant differences in the composition of microbial communities of healthy and tumor tissues and have made it possible to characterize the potential tumor microbiota in some types of cancer. The microbiota present in the various organs of the human body forms a network through which it interacts via migration or by forming metabolic axes between organs. Dysbiosis plays an important role in carcinogenesis, and its presence in one organ can negatively affect the condition of other distant organs and contribute to the development of pathological conditions in them.Conclusion. Numerous studies conducted over the past decade have revealed a complex relationship between microorganisms, tumors, and the host, reflecting the diverse effects of the microbiota on various organ- specific types of MNs. Gastrointestinal tract tumors, as well as sites outside it with significant bacterial associations, have been identified for a better understanding of the multifaceted mechanisms by which the microbiota influences cancer. The data obtained so far complement the emerging possibilities of using the microbiota in clinical practice, which represents a new approach to the prevention and treatment of malignant neoplasms.

Keywords

• microbiota
• microbiome
• malignant neoplasms
• carcinogenesis
• mechanisms
• epidemiological studies