Nature Communications (Jul 2022)

Nestin-dependent mitochondria-ER contacts define stem Leydig cell differentiation to attenuate male reproductive ageing

  • Senyu Yao,
  • Xiaoyue Wei,
  • Wenrui Deng,
  • Boyan Wang,
  • Jianye Cai,
  • Yinong Huang,
  • Xiaofan Lai,
  • Yuan Qiu,
  • Yi Wang,
  • Yuanjun Guan,
  • Jiancheng Wang

DOI
https://doi.org/10.1038/s41467-022-31755-w
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

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The regulatory mechanisms contributing to male reproductive ageing are unknown. Here, the authors show that Nestin-dependent mito-ER contacts (MERCs) regulate stem Leydig cell (SLC) senescence and provide insights into SLCs-targeting therapies.