Three New Myrsinol Diterpenes from <em>Euphorbia prolifera</em> and Their Neuroprotective Activities

Abstract

Three new myrsinol diterpenes were isolated from the roots of<em> </em><em>Euphorbia prolifera</em>. Their structures were elucidated as 2<em>α</em>-<em>O</em>-isobutyryl-3<em>β</em>,5<em>α</em>,7<em>β</em>,10,15<em>β</em>-penta-<em>O</em>-acetyl-14<em>α</em>-<em>O</em>-benzoyl-10,18-dihydromyrsinol (<strong>1</strong>), 2<em>α</em>-<em>O</em>-isobutyryl-3<em>β</em>-<em>O</em>-propion-yl-5<em>α</em>,7<em>β</em>,10,15<em>β</em>-tetra-<em>O</em>-acetyl-10,18-dihydromyrsinol (<strong>2</strong>), and 2<em>α</em>,14<em>α</em>-di-<em>O</em>-benzoyl-3<em>β</em>,5<em>α</em>,7<em>β</em>,10,15<em>β</em>-penta-<em>O</em>-acetyl-10,18-dihydromyrsinol (<strong>3</strong>) on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR). Their neuroprotective activities were evaluated and compounds <strong>1</strong> and <strong>2</strong> showed neuroprotective effects against MPP⁺-induced neuronal cell death in SH-SY5Y cells.<strong></strong>

Keywords

• &lt;em&gt;Euphorbia prolifera&lt;/em&gt;
• diterpenoids
• myrsinol diterpenes
• neuroprotective activities&lt;em&gt;&lt;/em&gt;