Nature Communications (Aug 2022)

Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse

  • Jan Bláha,
  • Tereza Skálová,
  • Barbora Kalousková,
  • Ondřej Skořepa,
  • Denis Cmunt,
  • Valéria Grobárová,
  • Samuel Pazicky,
  • Edita Poláchová,
  • Celeste Abreu,
  • Jan Stránský,
  • Tomáš Kovaľ,
  • Jarmila Dušková,
  • Yuguang Zhao,
  • Karl Harlos,
  • Jindřich Hašek,
  • Jan Dohnálek,
  • Ondřej Vaněk

DOI
https://doi.org/10.1038/s41467-022-32577-6
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

NKR-P1 is an inhibitory receptor on the surface of natural killer cells, and its engagement with the ligand LLT1 on activated monocytes and B cells triggers NK cell self-tolerance and other immunological processes. Here authors set up a comprehensive, structure-based model of NKR-P1-LLT1 interaction that involves NKR-P1 homodimer formation and subsequent bridging of two LLT1 molecules.