Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits

Joshua M. Wang; Andrew L. Woodruff; Matthew J. Dunn; Robert J. Fillinger; Richard J. Bennett; Matthew Z. Anderson

doi:10.1128/mBio.00586-21

mBio (Apr 2021)

Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits

Joshua M. Wang,
Andrew L. Woodruff,
Matthew J. Dunn,
Robert J. Fillinger,
Richard J. Bennett,
Matthew Z. Anderson

Affiliations

Joshua M. Wang: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Andrew L. Woodruff: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Matthew J. Dunn: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Robert J. Fillinger: Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
Richard J. Bennett: Department of Molecular Microbiology and Immunology, Brown University, Providence, Rhode Island, USA
Matthew Z. Anderson: ORCiD; Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

DOI: https://doi.org/10.1128/mBio.00586-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Infectious fungal species are often treated uniformly despite clear evidence of genotypic and phenotypic heterogeneity being widespread across strains. Identifying the genetic basis for this phenotypic diversity is extremely challenging because of the tens or hundreds of thousands of variants that may distinguish two strains.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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