Biomimetic nanoflowers by self-assembly of nanozymes to induce intracellular oxidative damage against hypoxic tumors

Abstract

Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.