Effects of the 2% supramolecular complex of ivermectin in overdoses on horses

Abstract

The purpose of the research is to study effects of the 2.0% supramolecular complex of ivermectin in overdoses on the clinical condition of horses.Materials and methods. The experiment was conducted on 20 horses of different breeds in the Seradin Equestrian Center, the North Caucasus Federal District, the Chechen Republic, in October 2020. The horses were divided according to the principle of analogues into 3 test groups and one control group of 5 animals each. The 2.0% supramolecular complex of ivermectin was administered to the horses from group 1 at a therapeutic dose of 0.2 mg/kg; group 2 received a tripled dose of 0.6 mg/kg, and the group 3, a 5-fold increased dose of 1,0 mg/kg for the active substance. The drug was administered once individually in a mixture with compound feed. The body temperature was measured with a non-contact thermometer, and the pulse rate and the respiratory rate were measured per 1 min. Urine of the horses was examined on days 1, 7 and 14 after the drug. The urine color, transparency and consistency were determined. Multifunctional test paper was used to study pH, protein, glucose, ketone bodies, nitrites, bilirubin, and urobilinogen. Blood was taken in the morning from the horses’ jugular vein on days 1, 7 and 14 after the drug. Hematological and biochemical parameters were studied on analyzers.Results and discussion. Clinical fndings of the horses (body temperature, pulse and respiration) did not differ from those of the control animals after the 2.0% supramolecular complex of ivermectin was administered in a therapeutic, tripled and 5-fold increased doses on days 1, 7 and 14. A slight increase in ketone bodies was observed in the urine on day 1, which may indicate the drug effect on the central nervous system at a 5-fold increased dose; all parameters were within the normal range on days 7 and 14. The 2.0% supramolecular complex of ivermectin in overdoses (0.6; 1.0 mg/kg for the active substance) did not adversely affect the horses’ hematological or biochemical blood parameters.

Keywords

• supramolecular complex
• ivermectin
• clinical condition
• hematology
• biochemistry
• horses