Effi ciency of allogenic platelet-rich plasmsa, combined with collagen, in rat's humerus injury healing

Abstract

In experiment we studied influence of collagen, filled with platelet-rich plasma (PRP), on rats' bone regeneration in distal humerus. Used dose of PRP contained 130–135 pg/ml platelet-derived growth factor (PDGF). According to this level of PDGF, PRP-collagen treatment rapidly enhanced trabecular bones' growth, stimu-lated angiogenesis and reduced intensity of inflammation. Allogenic PRP, addressed to all experimental animals, allowed to make humerus healing 2 times shorter.

Keywords

• platelet rich plasma
• platelets with granules
• pdgf
• osteogenesis