Nature Communications (May 2020)

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

  • Xueyi Shen,
  • David M. Howard,
  • Mark J. Adams,
  • W. David Hill,
  • Toni-Kim Clarke,
  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium,
  • Ian J. Deary,
  • Heather C. Whalley,
  • Andrew M. McIntosh

DOI
https://doi.org/10.1038/s41467-020-16022-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.