Novel 3,6-Disubstituted Pyridazine Derivatives Targeting JNK1 Pathway: Scaffold Hopping and Hybridization-Based Design, Synthesis, Molecular Modeling, and In Vitro and In Vivo Anticancer Evaluation

• Mai M. Shaalan,
• Essam Eldin A. Osman,
• Yasmeen M. Attia,
• Olfat A. Hammam,
• Riham F. George,
• Bassem H. Naguib

Affiliations

Mai M. Shaalan

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Essam Eldin A. Osman

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Yasmeen M. Attia

Pharmacology Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt

Olfat A. Hammam

Pathology Department, Theodor Bilharz Research Institute, Imbaba, Giza, Egypt

Riham F. George

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Bassem H. Naguib

Pharmaceutical Chemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt