Optical methods in the study of drug chiral proporties. I. Valine in aqueous solutions with different deuterium content

Abstract

Two optical methods - polarimetry and laser light diffraction - have been used to study valine aqueous solutions. It has been shown that optical activity of valine enantiomers depends on deuterium content in aqueous solutions. The influence of deuterium-dependant heterophase clusters of water on optical activity of valine aqueous solutions has been discussed.

Keywords

• хиральная чистота лекарственных средств
• поляриметрия
• лазерная дифракция света
• соотношение дейтерий/протий в воде
• drug chiral purity
• polarimetry
• laser light diffraction
• deuterium/protium ratio in water