Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling

Prasanna K. Santhekadur; Maaged Akiel; Luni Emdad; Rachel Gredler; Jyoti Srivastava; Devaraja Rajasekaran; Chadia L. Robertson; Nitai D. Mukhopadhyay; Paul B. Fisher; Devanand Sarkar

doi:10.1016/j.fob.2014.03.012

FEBS Open Bio (Jan 2014)

Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling

Prasanna K. Santhekadur,
Maaged Akiel,
Luni Emdad,
Rachel Gredler,
Jyoti Srivastava,
Devaraja Rajasekaran,
Chadia L. Robertson,
Nitai D. Mukhopadhyay,
Paul B. Fisher,
Devanand Sarkar

Affiliations

Prasanna K. Santhekadur: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Maaged Akiel: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Luni Emdad: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Rachel Gredler: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Jyoti Srivastava: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Devaraja Rajasekaran: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Chadia L. Robertson: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Nitai D. Mukhopadhyay: Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, United States
Paul B. Fisher: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States
Devanand Sarkar: Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, United States

DOI: https://doi.org/10.1016/j.fob.2014.03.012
Journal volume & issue: Vol. 4, no. C
pp. 353 – 361

Abstract

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Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells. We now document that SND1 increases angiotensin II type 1 receptor (AT1R) levels by increasing AT1R mRNA stability. This results in activation of ERK, Smad2 and subsequently the TGFβ signaling pathway, promoting epithelial–mesenchymal transition (EMT) and migration and invasion by human HCC cells. A positive correlation was observed between SND1 and AT1R expression levels in human HCC patients. Small molecule inhibitors of SND1, alone or in combination with AT1R blockers, might be an effective therapeutic strategy for late-stage aggressive HCC.

Published in FEBS Open Bio

ISSN: 2211-5463 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://febs.onlinelibrary.wiley.com/journal/22115463

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