Nature Communications (Feb 2022)
ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis
- Christophe Royer,
- Elizabeth Sandham,
- Elizabeth Slee,
- Falk Schneider,
- Christoffer B. Lagerholm,
- Jonathan Godwin,
- Nisha Veits,
- Holly Hathrell,
- Felix Zhou,
- Karolis Leonavicius,
- Jemma Garratt,
- Tanaya Narendra,
- Anna Vincent,
- Celine Jones,
- Tim Child,
- Kevin Coward,
- Chris Graham,
- Marco Fritzsche,
- Xin Lu,
- Shankar Srinivas
Affiliations
- Christophe Royer
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Elizabeth Sandham
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Elizabeth Slee
- Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
- Falk Schneider
- MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Christoffer B. Lagerholm
- Wolfson Imaging Centre Oxford, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford
- Jonathan Godwin
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Nisha Veits
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Holly Hathrell
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Felix Zhou
- Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
- Karolis Leonavicius
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Jemma Garratt
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Tanaya Narendra
- Department of Physiology, Anatomy and Genetics, University of Oxford
- Anna Vincent
- Oxford Fertility, Institute of Reproductive Sciences, Oxford Business Park North
- Celine Jones
- Nuffield Department of Women’s and Reproductive Health, University of Oxford, Level 3, Women’s Centre, John Radcliffe Hospital
- Tim Child
- Nuffield Department of Women’s and Reproductive Health, University of Oxford, Level 3, Women’s Centre, John Radcliffe Hospital
- Kevin Coward
- Nuffield Department of Women’s and Reproductive Health, University of Oxford, Level 3, Women’s Centre, John Radcliffe Hospital
- Chris Graham
- Nuffield Department of Women’s and Reproductive Health, University of Oxford, Level 3, Women’s Centre, John Radcliffe Hospital
- Marco Fritzsche
- Kennedy Institute for Rheumatology, University of Oxford
- Xin Lu
- Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
- Shankar Srinivas
- Department of Physiology, Anatomy and Genetics, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-022-28590-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
The early embryo maintains its structure in the face of large mechanical stresses during morphogenesis. Here they show that ASPP2 acts to preserve epithelial integrity in regions of high apical tension during early development.
