Neural like cells and acetyl-salicylic acid alter rat brain structure and function following transient middle cerebral artery occlusion

Abstract

Transient cerebral ischemia is a pandemic neurological disorder and the main aim of medical intervention is to reduce complications. Human umbilical cord mesenchymal cells (hUCMs) are capable of differentiating into neural-like cells (NLC) in vitro, therefore we investigated the neuroprotective potential of these cells in comparison to aspirin and in combination (NLC-Aspirin) on spatial memory and neural morphologic changes in male rats submitted to transient cerebral ischemia.

Keywords

• ischemic stroke
• neural like cell
• aspirin
• ttc staining
• learning and memory