TAK1 inhibition effectively suppresses NLRP3 inflammasome-mediated inflammation and osteoclastic bone resorption in rheumatoid arthritis

• Hirofumi Tenshin,
• Jumpei Teramachi,
• Masahiro Hiasa,
• Asuka Oda,
• Takeshi Harada,
• Masahiro Oura,
• Kimiko Sogabe,
• Mohannad Ashtar,
• Kotaro Tanimoto,
• So Shimizu,
• Yoshiki Higa,
• Eiji Tanaka,
• Toshio Matsumoto,
• Masahiro Abe

Affiliations

Hirofumi Tenshin

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan; Corresponding author.

Jumpei Teramachi

Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Masahiro Hiasa

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Asuka Oda

Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Takeshi Harada

Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Masahiro Oura

Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Kimiko Sogabe

Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Mohannad Ashtar

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Kotaro Tanimoto

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

So Shimizu

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Yoshiki Higa

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Eiji Tanaka

Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan

Toshio Matsumoto

Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima, Japan

Masahiro Abe

Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan