Nature Communications (Jul 2020)
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
- Tadatoshi Sato,
- Shiv Verma,
- Christian D. Castro Andrade,
- Maureen Omeara,
- Nia Campbell,
- Jialiang S. Wang,
- Murat Cetinbas,
- Audrey Lang,
- Brandon J. Ausk,
- Daniel J. Brooks,
- Ruslan I. Sadreyev,
- Henry M. Kronenberg,
- David Lagares,
- Yuhei Uda,
- Paola Divieti Pajevic,
- Mary L. Bouxsein,
- Ted S. Gross,
- Marc N. Wein
Affiliations
- Tadatoshi Sato
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Shiv Verma
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Christian D. Castro Andrade
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Maureen Omeara
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Nia Campbell
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Jialiang S. Wang
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Murat Cetinbas
- Department of Molecular Biology and Department of Pathology, Massachusetts General Hospital, Harvard Medical School
- Audrey Lang
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Brandon J. Ausk
- Department of Orthopaedics and Sports Medicine, University of Washington
- Daniel J. Brooks
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Ruslan I. Sadreyev
- Department of Molecular Biology and Department of Pathology, Massachusetts General Hospital, Harvard Medical School
- Henry M. Kronenberg
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- David Lagares
- Center for Immunology and Inflammatory Diseases, Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School
- Yuhei Uda
- Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University
- Paola Divieti Pajevic
- Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University
- Mary L. Bouxsein
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- Ted S. Gross
- Department of Orthopaedics and Sports Medicine, University of Washington
- Marc N. Wein
- Endocrine Unit, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-17099-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific gene expression.
