CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

Saumil Sethna; Patrick A. Scott; Arnaud P. J. Giese; Todd Duncan; Xiaoying Jian; Sheikh Riazuddin; Paul A. Randazzo; T. Michael Redmond; Steven L. Bernstein; Saima Riazuddin; Zubair M. Ahmed

doi:10.1038/s41467-021-24056-1

Nature Communications (Jun 2021)

CIB2 regulates mTORC1 signaling and is essential for autophagy and visual function

Saumil Sethna,
Patrick A. Scott,
Arnaud P. J. Giese,
Todd Duncan,
Xiaoying Jian,
Sheikh Riazuddin,
Paul A. Randazzo,
T. Michael Redmond,
Steven L. Bernstein,
Saima Riazuddin,
Zubair M. Ahmed

Affiliations

Saumil Sethna: Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine
Patrick A. Scott: Department of Ophthalmology & Visual Sciences, University of Louisville
Arnaud P. J. Giese: Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine
Todd Duncan: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health
Xiaoying Jian: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health
Sheikh Riazuddin: Allama Iqbal Medical College, University of Health Sciences
Paul A. Randazzo: Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health
T. Michael Redmond: Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health
Steven L. Bernstein: Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine
Saima Riazuddin: Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine
Zubair M. Ahmed: Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine

DOI: https://doi.org/10.1038/s41467-021-24056-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

Read online

Age-related macular degeneration (AMD) has been connected to deficits in autophagy. Here, the authors demonstrate, in mice and dry-AMD patient samples, that calcium and integrin binding protein 2 (CIB2) regulates Rheb-mTORC1 signaling axis, and subsequently autophagy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal