Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

Erliang Guo MD; Lunhua Guo MD; Changming An MD; Cong Zhang MD; Kaibin Song MD; Guohui Wang MD; Chunbin Duan MD; Xiwei Zhang MD; Xianguang Yang MD; Zhennan Yuan MD; Junnan Guo MD; Ji Sun MD; Hongxue Meng MD; Rui Chang MD; Xiaomei Li MD; Cheng Xiu MD; Xionghui Mao MD; Susheng Miao MD

doi:10.1177/1073274820978795

Cancer Control (Dec 2020)

Prognostic Significance of Lactate Dehydrogenase in Patients Undergoing Surgical Resection for Laryngeal Squamous Cell Carcinoma

Erliang Guo MD,
Lunhua Guo MD,
Changming An MD,
Cong Zhang MD,
Kaibin Song MD,
Guohui Wang MD,
Chunbin Duan MD,
Xiwei Zhang MD,
Xianguang Yang MD,
Zhennan Yuan MD,
Junnan Guo MD,
Ji Sun MD,
Hongxue Meng MD,
Rui Chang MD,
Xiaomei Li MD,
Cheng Xiu MD,
Xionghui Mao MD,
Susheng Miao MD

Affiliations

Erliang Guo MD: * These two authors have contributed equally to the work.
Lunhua Guo MD: * These two authors have contributed equally to the work.
Changming An MD: Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital. Beijing 100000, China
Cong Zhang MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Kaibin Song MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Guohui Wang MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Chunbin Duan MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Xiwei Zhang MD: Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital. Beijing 100000, China
Xianguang Yang MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Zhennan Yuan MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Junnan Guo MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Ji Sun MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Hongxue Meng MD: Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China
Rui Chang MD: Department of Head and Neck Surgery, Anyang Cancer Hospital, Anyang 455000, China
Xiaomei Li MD: Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China
Cheng Xiu MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Xionghui Mao MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China
Susheng Miao MD: Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, Harbin 150081, China

DOI: https://doi.org/10.1177/1073274820978795
Journal volume & issue: Vol. 27

Abstract

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The aim is to estimate the prognostic value of lactate dehydrogenase (LDH) in patients undergoing surgical resection for laryngeal squamous cell carcinoma (LSCC). A total of 640 resected LSCC patients were included. Preoperative lactate dehydrogenase (LDH) was assessed. Kaplan-Meier survival analysis and Cox regression analysis were conducted for overall survival (OS) and recurrence-free survival (RFS). Kaplan-Meier analysis, univariate analysis and multivariate analysis demonstrated significant prognostic value for preoperative LDH. Although LDH was predictor of OS, it failed to be a predictor of RFS. The univariate HR and 95% CI of LDH were 0.484 and 0.357-0.658 (P 132 IU/L was significantly associated with better survival. Preoperative LDH might be an independent prognostic marker of OS in LSCC patients undergoing surgical resection.

Published in Cancer Control

ISSN: 1073-2748 (Print); 1526-2359 (Online)
Publisher: SAGE Publishing
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://journals.sagepub.com/home/ccx

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