Nature Communications (Dec 2021)
Proximal and distal effects of genetic susceptibility to multiple sclerosis on the T cell epigenome
- Tina Roostaei,
- Hans-Ulrich Klein,
- Yiyi Ma,
- Daniel Felsky,
- Pia Kivisäkk,
- Sarah M. Connor,
- Alexandra Kroshilina,
- Christina Yung,
- Belinda J. Kaskow,
- Xiaorong Shao,
- Brooke Rhead,
- José M. Ordovás,
- Devin M. Absher,
- Donna K. Arnett,
- Jia Liu,
- Nikolaos Patsopoulos,
- Lisa F. Barcellos,
- Howard L. Weiner,
- Philip L. De Jager
Affiliations
- Tina Roostaei
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Hans-Ulrich Klein
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Yiyi Ma
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Daniel Felsky
- Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, University of Toronto
- Pia Kivisäkk
- Alzheimer’s Clinical and Translational Research Unit, Department of Neurology, Massachusetts General Hospital
- Sarah M. Connor
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Alexandra Kroshilina
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Christina Yung
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- Belinda J. Kaskow
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Xiaorong Shao
- Genetic Epidemiology and Genomics Laboratory, University of California
- Brooke Rhead
- Genetic Epidemiology and Genomics Laboratory, University of California
- José M. Ordovás
- Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University
- Devin M. Absher
- HudsonAlpha Institute for Biotechnology
- Donna K. Arnett
- College of Public Health, University of Kentucky
- Jia Liu
- Advanced Science Research Center at the Graduate Center, Neuroscience Initiative, City University of New York
- Nikolaos Patsopoulos
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Lisa F. Barcellos
- Genetic Epidemiology and Genomics Laboratory, University of California
- Howard L. Weiner
- Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School
- Philip L. De Jager
- Center for Translational and Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer’s disease and the Aging brain, Columbia University Irving Medical Center
- DOI
- https://doi.org/10.1038/s41467-021-27427-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Integrating functional data with GWAS loci can help interpret the function of genetic variants associated with disease. Here the authors map cis and trans methylation QTL in CD4 + T cells from patients and colocalize with GWAS loci in order to interpret genetic variants associated with multiple sclerosis.
