Nature Communications (Nov 2021)

Bi-directional ribosome scanning controls the stringency of start codon selection

  • Yifei Gu,
  • Yuanhui Mao,
  • Longfei Jia,
  • Leiming Dong,
  • Shu-Bing Qian

DOI
https://doi.org/10.1038/s41467-021-26923-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.