Clinical, Cosmetic and Investigational Dermatology (Mar 2023)
A Case of Neutrophilic Dermatoses-Sweet’s Syndrome Coexisting with SAPHO Syndrome
Abstract
Mingwei Ma,1,* Shufeng Wei,2,* Dan Yin,2 Weizhong Li,2 Chen Li2 1School of Clinical Medicine, Peking Union Medical College Hospital (PUMC and CAMS), Beijing, 100730, People’s Republic of China; 2Department of Rheumatology, Fangshan Hospital Beijing University of Chinese Medicine, Beijing, 102401, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chen Li, Department of Rheumatology, Fangshan Hospital, Beijing University of Chinese Medicine, No. 4, Chengguan Health Road, Fangshan District, Beijing, People’s Republic of China, Tel +86 13810988688, Email [email protected]: SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a rare disease characterized by osteoarticular and cutaneous manifestations. SAPHO syndrome mostly involves the skin, mainly presented as palmoplantar pustulosis and severe acne. Sweet’s syndrome (SS) is a neutrophilic dermatosis of unknown cause, which may be caused by autoinflammation. So far, SAPHO syndrome complicated with SS has been rarely reported worldwide. Here, we present a rare case diagnosed in our hospital with detailed clinical information. This patient presented pain and swelling in her right leg. Later, she developed red papules on her right lower eyelid and a skin biopsy showed diffuse lymphocytic and neutrophilic infiltration in the superficial dermis. She was diagnosed with SAPHO syndrome and SS according to medical history and examination. These two diseases share parts of autoinflammatory signaling pathways and might be different variations of the spectrum of autoinflammatory diseases. Through this case, we aim to provide a new horizon for the regulation of neutrophils in SAPHO syndrome and skin lesions like SS.Keywords: SAPHO syndrome, Sweet’s syndrome, autoinflammation disease
