Nature Communications (Feb 2020)
A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy
- Bin Chen,
- Cenglin Xu,
- Yi Wang,
- Wenkai Lin,
- Ying Wang,
- Liying Chen,
- Heming Cheng,
- Lingyu Xu,
- Tingting Hu,
- Junli Zhao,
- Ping Dong,
- Yi Guo,
- Shihong Zhang,
- Shuang Wang,
- Yudong Zhou,
- Weiwei Hu,
- Shuming Duan,
- Zhong Chen
Affiliations
- Bin Chen
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Cenglin Xu
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Yi Wang
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Wenkai Lin
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Ying Wang
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Liying Chen
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Heming Cheng
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Lingyu Xu
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Tingting Hu
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Junli Zhao
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Ping Dong
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Yi Guo
- Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University
- Shihong Zhang
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Shuang Wang
- Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University
- Yudong Zhou
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Weiwei Hu
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Shuming Duan
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- Zhong Chen
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Department of Pharmacology, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University
- DOI
- https://doi.org/10.1038/s41467-020-14648-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of this circuit can alleviate severity of epileptic seizures.
