Nature Communications (Aug 2022)
Acetate reprograms gut microbiota during alcohol consumption
- Cameron Martino,
- Livia S. Zaramela,
- Bei Gao,
- Mallory Embree,
- Janna Tarasova,
- Seth J. Parker,
- Yanhan Wang,
- Huikuan Chu,
- Peng Chen,
- Kuei-Chuan Lee,
- Daniela Domingos Galzerani,
- Jivani M. Gengatharan,
- Asama Lekbua,
- Maxwell Neal,
- Rob Knight,
- Hidekazu Tsukamoto,
- Christian M. Metallo,
- Bernd Schnabl,
- Karsten Zengler
Affiliations
- Cameron Martino
- Department of Pediatrics, University of California San Diego
- Livia S. Zaramela
- Department of Pediatrics, University of California San Diego
- Bei Gao
- Department of Medicine, University of California San Diego
- Mallory Embree
- Department of Bioengineering, University of California
- Janna Tarasova
- Department of Pediatrics, University of California San Diego
- Seth J. Parker
- Department of Bioengineering, University of California
- Yanhan Wang
- Department of Medicine, University of California San Diego
- Huikuan Chu
- Department of Medicine, University of California San Diego
- Peng Chen
- Department of Medicine, University of California San Diego
- Kuei-Chuan Lee
- Department of Medicine, University of California San Diego
- Daniela Domingos Galzerani
- Department of Pediatrics, University of California San Diego
- Jivani M. Gengatharan
- Department of Bioengineering, University of California
- Asama Lekbua
- Department of Pediatrics, University of California San Diego
- Maxwell Neal
- Department of Pediatrics, University of California San Diego
- Rob Knight
- Department of Pediatrics, University of California San Diego
- Hidekazu Tsukamoto
- Southern California Research Center for ALPD and Cirrhosis and Department of Pathology
- Christian M. Metallo
- Department of Bioengineering, University of California
- Bernd Schnabl
- Center for Microbiome Innovation, University of California San Diego
- Karsten Zengler
- Department of Pediatrics, University of California San Diego
- DOI
- https://doi.org/10.1038/s41467-022-31973-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Chronic alcohol use is associated with intestinal bacterial overgrowth and dysbiosis, but the contribution of ethanol is unclear. Here, using mouse models, the authors find that ethanol is not directly metabolized by the gut microbiota, and that induced changes are rather a side effect of elevated acetate levels.
