Scientific Reports (Mar 2021)

Habitual fish intake negatively correlates with prevalence of frailty among patients with rheumatoid arthritis

  • Hiroto Minamino,
  • Masao Katsushima,
  • Mie Torii,
  • Motomu Hashimoto,
  • Yoshihito Fujita,
  • Kaori Ikeda,
  • Wataru Yamamoto,
  • Ryu Watanabe,
  • Kosaku Murakami,
  • Koichi Murata,
  • Kohei Nishitani,
  • Masao Tanaka,
  • Hiromu Ito,
  • Koichiro Ohmura,
  • Hidenori Arai,
  • Nobuya Inagaki,
  • Shuichi Matsuda

DOI
https://doi.org/10.1038/s41598-021-84479-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Abstract Frailty is a geriatric syndrome characterized by anabolic-catabolic imbalance and multisystem dysregulation resulting in increased adverse health outcomes, and is closely related with dietary habits in the general population. Although chronic inflammatory diseases are thought to accelerate development of frailty, correlations between rheumatoid arthritis (RA), frailty and dietary habits have not been examined. We performed a cross-sectional study using our cohort database (KURAMA cohort), and classified 306 participants into three groups (robust, prefrail and frail) according to the Study of Osteoporotic Fracture (SOF) criteria. Multivariate logistic analysis revealed that the presence of frailty/prefrailty was significantly correlated with the disease activity score (DAS28-ESR) (OR 1.70 (1.30–2.22), p two times a week) was an independent covariate negatively correlated with frailty/prefrailty (OR 0.35 (0.19–0.63), p = 0.00060). In conclusion, habitual fish intake may play a key role in nutritional intervention to prevent progression of frailty and RA.