Scientific Reports (Apr 2021)
Investigation of triple-negative breast cancer risk alleles in an International African-enriched cohort
- Rachel Martini,
- Yalei Chen,
- Brittany D. Jenkins,
- Isra A. Elhussin,
- Esther Cheng,
- Syed A. Hoda,
- Paula S. Ginter,
- Jeffrey Hanover,
- Rozina B. Zeidan,
- Joseph K. Oppong,
- Ernest K. Adjei,
- Aisha Jibril,
- Dhananjay Chitale,
- Jessica M. Bensenhaver,
- Baffour Awuah,
- Mahteme Bekele,
- Engida Abebe,
- Ishmael Kyei,
- Frances S. Aitpillah,
- Michael O. Adinku,
- Kwasi Ankomah,
- Ernest B. Osei-Bonsu,
- Saul David Nathansan,
- LaToya Jackson,
- Evelyn Jiagge,
- Lindsay F. Petersen,
- Erica Proctor,
- Petros Nikolinakos,
- Kofi K. Gyan,
- Clayton Yates,
- Rick Kittles,
- Lisa A. Newman,
- Melissa B. Davis
Affiliations
- Rachel Martini
- Department of Surgery, Weill Cornell Medicine
- Yalei Chen
- Department of Public Health Sciences, Henry Ford Health System
- Brittany D. Jenkins
- Department of Surgery, Weill Cornell Medicine
- Isra A. Elhussin
- Department of Biology & Center for Cancer Research, Tuskegee University
- Esther Cheng
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Syed A. Hoda
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Paula S. Ginter
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Jeffrey Hanover
- Rutgers New Jersey Medical School
- Rozina B. Zeidan
- Department of Surgery, Weill Cornell Medicine
- Joseph K. Oppong
- Department of Surgery, Komfo Anokye Teaching Hospital
- Ernest K. Adjei
- Department of Pathology, Komfo Anokye Teaching Hospital
- Aisha Jibril
- Department of Pathology, St. Paul’s Hospital Millennium Medical College
- Dhananjay Chitale
- Department of Pathology, Henry Ford Health System
- Jessica M. Bensenhaver
- Department of Surgery, Henry Ford Health System
- Baffour Awuah
- Directorate of Oncology, Komfo Anokye Teaching Hospital
- Mahteme Bekele
- Department of Surgery, St. Paul’s Hospital Millennium Medical College
- Engida Abebe
- Department of Surgery, St. Paul’s Hospital Millennium Medical College
- Ishmael Kyei
- Department of Surgery, Kwame Nkrumah University of Science and Technology
- Frances S. Aitpillah
- Department of Surgery, Komfo Anokye Teaching Hospital
- Michael O. Adinku
- Department of Surgery, Kwame Nkrumah University of Science and Technology
- Kwasi Ankomah
- Directorate of Radiology, Komfo Anokye Teaching Hospital
- Ernest B. Osei-Bonsu
- Directorate of Oncology, Komfo Anokye Teaching Hospital
- Saul David Nathansan
- Department of Surgery, Henry Ford Health System
- LaToya Jackson
- Department of Public Health Sciences, Henry Ford Health System
- Evelyn Jiagge
- Department of Public Health Sciences, Henry Ford Health System
- Lindsay F. Petersen
- Department of Surgery, Henry Ford Health System
- Erica Proctor
- Department of Surgery, Henry Ford Health System
- Petros Nikolinakos
- University Cancer and Blood Center
- Kofi K. Gyan
- Department of Surgery, Weill Cornell Medicine
- Clayton Yates
- Department of Biology & Center for Cancer Research, Tuskegee University
- Rick Kittles
- Department of Population Sciences, City of Hope Comprehensive Cancer Center
- Lisa A. Newman
- Department of Surgery, Weill Cornell Medicine
- Melissa B. Davis
- Department of Surgery, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41598-021-88613-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Abstract Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new efforts to verify if these alleles increase risk in African American (AA) women as well. We investigated the effect of previously reported AA breast cancer and triple-negative breast cancer (TNBC) risk alleles in our African-enriched International Center for the Study of Breast Cancer Subtypes (ICSBCS) cohort. Using case–control, case-series and race-nested approaches, we report that the Duffy-null allele (rs2814778) is associated with TNBC risk (OR = 3.814, p = 0.001), specifically among AA individuals, after adjusting for self-indicated race and west African ancestry (OR = 3.368, p = 0.007). We have also validated the protective effect of the minor allele of the ANKLE1 missense variant rs2363956 among AA for TNBC (OR = 0.420, p = 0.005). Our results suggest that an ancestry-specific Duffy-null allele and differential prevalence of a polymorphic gene variant of ANKLE1 may play a role in TNBC breast cancer outcomes. These findings present opportunities for therapeutic potential and future studies to address race-specific differences in TNBC risk and disease outcome.
