A New Meroterpene, A New Benzofuran Derivative and Other Constituents from Cultures of the Marine Sponge-Associated Fungus <i>Acremonium persicinum</i> KUFA 1007 and Their Anticholinesterase Activities

Abstract

Previously unreported meroterpene, acremine S (1), and benzopyran derivative, acremine T (2), were isolated, together with lumichrome (3), ergosterol (4) and ergosterol 5,8-endoperoxide, from cultures of the marine sponge-associated fungus Acremonium persicinum KUF1007. The structure of the previously unreported compounds was established based on an extensive analysis of 1D and 2D NMR spectra as well as HRMS data. The absolute configurations of the stereogenic centers of 1 were established, unambiguously, based on NOESY correlations and comparison of calculated and experimental electronic circular dichroism (ECD) spectra. Compounds 1−3 were tested for their in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activities.

Keywords

• <i>Acremonium persicinum</i>
• Hypocreaceae
• marine sponge-associated fungus
• meroterpene
• acremine S
• acremine T
• benzofuran
• anticholinesterase activities