Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Huan Yang; Caroline Sibilla; Raymond Liu; Jina Yun; Bruce A. Hay; Craig Blackstone; David C. Chan; Robert J. Harvey; Ming Guo

doi:10.1038/s41467-022-29071-4

Nature Communications (Mar 2022)

Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria

Huan Yang,
Caroline Sibilla,
Raymond Liu,
Jina Yun,
Bruce A. Hay,
Craig Blackstone,
David C. Chan,
Robert J. Harvey,
Ming Guo

Affiliations

Huan Yang: Department of Neurology, UCLA David Geffen School of Medicine
Caroline Sibilla: Cell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke
Raymond Liu: Division of Biology and Biological Engineering, California Institute of Technology
Jina Yun: Department of Neurology, UCLA David Geffen School of Medicine
Bruce A. Hay: Division of Biology and Biological Engineering, California Institute of Technology
Craig Blackstone: Cell Biology Section, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke
David C. Chan: Division of Biology and Biological Engineering, California Institute of Technology
Robert J. Harvey: School of Health and Behavioural Sciences, University of the Sunshine Coast
Ming Guo: Department of Neurology, UCLA David Geffen School of Medicine

DOI: https://doi.org/10.1038/s41467-022-29071-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Drp1 is the master regulator of mitochondrial fission, which has important impact on cellular functions. Here, Yang et al identified evolutionarily conserved proteins Clueless and its homolog CLUH as key regulators of Drp1 that function via translation of Drp1 receptors MiD49 and Mff.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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