Benzaldehyde lyase-catalyzed enantioselective C–C bond formation and cleavage: A review

Zhiran Ju; Junde Xu; Zhiyun Li; Jingjie Fang; Menglan Li; Daniel C. Howell; FenEr Chen

Green Synthesis and Catalysis (Nov 2022)

Benzaldehyde lyase-catalyzed enantioselective C–C bond formation and cleavage: A review

Zhiran Ju,
Junde Xu,
Zhiyun Li,
Jingjie Fang,
Menglan Li,
Daniel C. Howell,
FenEr Chen

Affiliations

Zhiran Ju: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Junde Xu: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Zhiyun Li: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Jingjie Fang: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Menglan Li: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China
Daniel C. Howell: Department of Pharmaceutical Sciences, Oregon State University, Corvallis 97331, United States
FenEr Chen: Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China; Engineering Center of Catalysis and Synthesis for Chiral Molecules, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China; Corresponding author. Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.

Journal volume & issue: Vol. 3, no. 4
pp. 317 – 326

Abstract

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Benzaldehyde lyase (BAL) is an enzyme which was originally found from Pseudomonas fluorescens biovar I. It has long been used in the formation of a C–C bond. BAL can exclusively yield (R)-enantioselective products from the synthesis of α-hydroxy ketones and has so far been explored as an important enzyme to prepare the corresponding intermediate of pharmaceuticals. Due to its substrate spectrum and stereospecificity, this enzyme extends the synthetic potential for carboligations appreciably. In this review, we highlight the biotransformation applications of BAL in recent years, some of which have achieved intriguing results and provided the theoretical basis for drug development and industrial purpose in the future.

Published in Green Synthesis and Catalysis

ISSN: 2666-5549 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Technology: Chemical technology; Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/green-synthesis-and-catalysis/

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