Nature Communications (May 2022)
A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway
- Bhav Harshad Parikh,
- Zengping Liu,
- Paul Blakeley,
- Qianyu Lin,
- Malay Singh,
- Jun Yi Ong,
- Kim Han Ho,
- Joel Weijia Lai,
- Hanumakumar Bogireddi,
- Kim Chi Tran,
- Jason Y. C. Lim,
- Kun Xue,
- Abdurrahmaan Al-Mubaarak,
- Binxia Yang,
- Sowmiya R,
- Kakkad Regha,
- Daniel Soo Lin Wong,
- Queenie Shu Woon Tan,
- Zhongxing Zhang,
- Anand D. Jeyasekharan,
- Veluchamy Amutha Barathi,
- Weimiao Yu,
- Kang Hao Cheong,
- Timothy A. Blenkinsop,
- Walter Hunziker,
- Gopal Lingam,
- Xian Jun Loh,
- Xinyi Su
Affiliations
- Bhav Harshad Parikh
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Zengping Liu
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Paul Blakeley
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Qianyu Lin
- Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR)
- Malay Singh
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Jun Yi Ong
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Kim Han Ho
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Joel Weijia Lai
- Science, Mathematics and Technology Cluster, Singapore University of Technology and Design (SUTD)
- Hanumakumar Bogireddi
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Kim Chi Tran
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Jason Y. C. Lim
- Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR)
- Kun Xue
- Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR)
- Abdurrahmaan Al-Mubaarak
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Binxia Yang
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Sowmiya R
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Kakkad Regha
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Daniel Soo Lin Wong
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Queenie Shu Woon Tan
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Zhongxing Zhang
- Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR)
- Anand D. Jeyasekharan
- Cancer Science Institute of Singapore, National University of Singapore
- Veluchamy Amutha Barathi
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Weimiao Yu
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Kang Hao Cheong
- Science, Mathematics and Technology Cluster, Singapore University of Technology and Design (SUTD)
- Timothy A. Blenkinsop
- Department of Cellular, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai
- Walter Hunziker
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- Gopal Lingam
- Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore
- Xian Jun Loh
- Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR)
- Xinyi Su
- Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-022-30474-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
One common cause of vision loss after retinal detachment surgery is retinal scarring. Here the authors demonstrate that a bio-functional polymer can prevent retinal scarring by suppression of epithelial-mesenchymal transition and hyper-proliferation of retinal pigment epithelial cells.
