ANALYSIS OF THE PATIENTS REFERRED FOR TREATMENT TO NOVOSIBIRSK TUBERCULOSIS RESEARCH INSTITUTE FROM THE AREAS SUPERVISED BY THIS INSTITUTE. CHANGES IN CHEMOTHERAPY EFFICIENCY AFTER INTRODUCTION OF THE UPDATED TREATMENT REGIMENS AND MICROBIOLOGICAL DIAGNOSTICS

Abstract

In 2015 the implementation of Edicts no. 951 by the Russian Ministry of Health On Guidelines on Improvement of Respiratory Tuberculosis Treatment and Diagnostics was started.Goal of the study: to analyze the characteristics of tuberculosis patients referred to treatment to Novosibirsk Tuberculosis Research Institute (NTRI) in 2014-2016 from the areas supervised by the Institute; to evaluate the clinical assessment of comprehensive chemotherapy efficiency after the introduction of the updated treatment regimens and express methods of microbiological diagnostics.Materials and methods: a prospective cohort study was conducted using the data of 481 patients referred for treatment to NTRI from the areas supervised by it, i.e. Siberian and Far Eastern Federal Districts.Results. Among the patients referred for treatment to NTRI in 2014-2016, new tuberculosis cases with multiple/extensive drug resistance (64.3-80.5%) and pulmonary destructions (67.9-82.7%) were very frequent. Among the patients already receiving treatment and referred to NTRI, the part of those with progressing course of the disease reduced from 35.0% in 2014 down to 9.7% in 2016 as well as the part of those with concurrent bronchial tuberculosis reduced from 41.3% in 2014 down to 27.9% in 2016.After introduction of the provisions of the Edict to NTRI, treatment efficiency of new patients improved assessed as per the cessation of bacillary excretion (by sputum smear microscopy: in 2016 – 91.7%, in 2014 – 75%; by culture: in 2016 – 90.9%, in 2014 г. – 77.3%).

Keywords

• туберкулез легких
• множественная лекарственная устойчивость возбудителя
• широкая лекарственная устойчивость возбудителя
• результаты лечения